Calcium-activated neutral protease (calpain) system: structure, function, and regulation.
1991; American Physiological Society; Volume: 71; Issue: 3 Linguagem: Inglês
10.1152/physrev.1991.71.3.813
ISSN1522-1210
AutoresDorothy E. Croall, George Demartino,
Tópico(s)Neurological diseases and metabolism
ResumoCalcium-activated neutral protease (calpain) system: structure, function, and regulation.D E Croall, and G N DeMartinoD E CroallDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas., and G N DeMartinoDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas.Published Online:01 Jul 1991https://doi.org/10.1152/physrev.1991.71.3.813MoreSectionsPDF (10 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByPolymorphism analysis in genes associated with meat tenderness in Nelore cattleMeta Gene, Vol. 18Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects3 September 2018 | Scientific Reports, Vol. 8, No. 1Ca 2+ -depended signaling pathways regulate self-renewal and pluripotency of stem cells19 June 2018 | Cell Biology International, Vol. 42, No. 9Role of calpain system in meat tenderness: A reviewFood Science and Human WellnessEndothelial barrier dysfunction induced by nanoparticle exposure through actin remodeling via caveolae/raft-regulated calcium signallingNanoImpact, Vol. 11MiR-137–3p rescue motoneuron death by targeting calpain-2Nitric Oxide, Vol. 74Metabolic adaptability in hexavalent chromium-treated renal tissue: an in vivo study27 July 2017 | Clinical Kidney Journal, Vol. 11, No. 2Nimodipine attenuates the parkinsonian neurotoxin, MPTP-induced changes in the calcium binding proteins, calpain and calbindinJournal of Chemical NeuroanatomyMilk: An Effective Recovery Drink for Female Athletes17 February 2018 | Nutrients, Vol. 10, No. 2Aerobic Training Prevents Heatstrokes in Calsequestrin-1 Knockout Mice by Reducing Oxidative StressOxidative Medicine and Cellular Longevity, Vol. 2018Genomewide association mapping and pathway analysis of meat tenderness in Polled Nellore cattle1Journal of Animal Science, Vol. 95, No. 5Membrane permeability during pressure ulcer formation: A computational model of dynamic competition between cytoskeletal damage and repairJournal of Biomechanics, Vol. 49, No. 8The potential role of regucalcin in kidney cell regulation: Involvement in renal failure (Review)11 September 2015 | International Journal of Molecular Medicine, Vol. 36, No. 5Oxidative Stress and the Use of Antioxidants in Stroke3 July 2014 | Antioxidants, Vol. 3, No. 3Understanding the Interaction Determinants of CAPN1 Inhibition by CAST4 from Bovines Using Molecular Modeling Techniques11 September 2014 | Molecules, Vol. 19, No. 9Homology Modeling Study of Bovine μ-Calpain Inhibitor-Binding Domains6 May 2014 | International Journal of Molecular Sciences, Vol. 15, No. 5Alterations in the expression of atrial calpains in electrical and structural remodeling during aging and atrial fibrillation13 September 2013 | Molecular Medicine Reports, Vol. 8, No. 5Electroacupuncture, Calpain I Expression, and Survival of Hippocampal Neurons in Cerebral Ischemia Reperfusion RatsMedical Acupuncture, Vol. 22, No. 2Inhibition of calpain prevents muscle weakness and disruption of sarcomere structure during hindlimb suspensionJay J. 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Koh, and Joel Escobedo1 March 2004 | American Journal of Physiology-Cell Physiology, Vol. 286, No. 3The Role of Calpain in Oncotic Cell DeathAnnual Review of Pharmacology and Toxicology, Vol. 44, No. 1Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organizationExperimental Cell Research, Vol. 292, No. 1Activation of calcineurin expression in ischemia-reperfused rat heart and in human ischemic myocardium12 November 2003 | Journal of Cellular Biochemistry, Vol. 90, No. 5Plasmalemmal sealing of transected mammalian neurites is a gradual process mediated by Ca2+-regulated proteins21 October 2003 | Journal of Neuroscience Research, Vol. 74, No. 4Vitamin D-induced apoptosis and melanoma: does calpain represent the major execution protease rather than caspases?1 January 2003 | The Journal of Pathology, Vol. 201, No. 2Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cellsExperimental Cell Research, Vol. 289, No. 2The calpains in aging and aging-related diseasesAgeing Research Reviews, Vol. 2, No. 4Association of the calpain/calpastatin network with subcellular organellesBiochemical and Biophysical Research Communications, Vol. 310, No. 4Oxidized Lipoproteins Inhibit Surfactant Phosphatidylcholine Synthesis via Calpain-mediated Cleavage of CTP:Phosphocholine Cytidylyltransferase11 July 2003 | Journal of Biological Chemistry, Vol. 278, No. 39Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicantsToxicology and Applied Pharmacology, Vol. 191, No. 3Calpain Regulates Enterocyte Brush Border Actin Assembly and Pathogenic Escherichia coli -mediated Effacement22 May 2003 | Journal of Biological Chemistry, Vol. 278, No. 32Synthesis and evaluation of fluorescent probes for the detection of calpain activityAnalytical Biochemistry, Vol. 319, No. 2Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallinsBiochemical and Biophysical Research Communications, Vol. 307, No. 3m-Calpain Colocalizes with the Calcium-sensing Receptor (CaR) in Caveolae in Parathyroid Cells and Participates in Degradation of the CaRJournal of Biological Chemistry, Vol. 278, No. 33The Calpain SystemDARREL E. GOLL, VALERY F. THOMPSON, HONGQI LI, WEI WEI, and JINYANG CONG1 July 2003 | Physiological Reviews, Vol. 83, No. 3Microtubule-associated protein 2 (MAP2) associates with the NMDA receptor and is spatially redistributed within rat hippocampal neurons after oxygen-glucose deprivationBrain Research, Vol. 978, No. 1-2Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acidNeurochemistry International, Vol. 43, No. 2Regulation of cell death: the calcium–apoptosis linkNature Reviews Molecular Cell Biology, Vol. 4, No. 7Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitorsBrain Research Reviews, Vol. 42, No. 2A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulinMetabolism, Vol. 52, No. 5Cross-talk between Calpain and Caspase Proteolytic Systems During Neuronal Apoptosis7 February 2003 | Journal of Biological Chemistry, Vol. 278, No. 16Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin1 January 2003 | The Journal of Pathology, Vol. 199, No. 4Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lensExperimental Eye Research, Vol. 76, No. 4MAP Kinase-dependent Degradation of p27Kip1 by Calpains in Choroidal Melanoma CellsJournal of Biological Chemistry, Vol. 278, No. 14Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain5 February 2003 | Oncogene, Vol. 22, No. 5The Calpastatin-Derived Calpain Inhibitor CP1B Reduces mRNA Expression of Matrix Metalloproteinase-2 and -9 and Invasion by Leukemic THP-1 CellsBiological Chemistry, Vol. 384, No. 6The protease core of the muscle-specific calpain, p94, undergoes Ca 2+ -dependent intramolecular autolysis23 November 2002 | FEBS Letters, Vol. 532, No. 3Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin isoform expression during murine muscle disuse1 December 2002 | The Journal of Physiology, Vol. 545, No. 3Contribution of Ubiquitous Calpains to Cataractogenesis in the Spontaneous Diabetic WBN/Kob RatExperimental Eye Research, Vol. 75, No. 5Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor proteinMolecular Brain Research, Vol. 107, No. 2Domain V of m-calpain shows the potential to form an oblique-orientated α-helix, which may modulate the enzyme's activity via interactions with anionic lipid30 October 2002 | European Journal of Biochemistry, Vol. 269, No. 22Mechanisms of Muscle Injury Gleaned from Animal ModelsAmerican Journal of Physical Medicine & Rehabilitation, Vol. 81, No. SupplementSNAP-23 Is a Target for Calpain Cleavage in Activated Platelets16 July 2002 | Journal of Biological Chemistry, Vol. 277, No. 40Desmin cytoskeletal modifications after a bout of eccentric exercise in the ratIlona A. 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Lefer1 April 2002 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 282, No. 4v-SRC'S hold over actin and cell adhesions1 April 2002 | Nature Reviews Molecular Cell Biology, Vol. 3, No. 4A Ca2+ Switch Aligns the Active Site of CalpainCell, Vol. 108, No. 5Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR)2 July 2009 | Current Eye Research, Vol. 25, No. 4Calpains mediate acute renal cell death: role of autolysis and translocationXiuli Liu, Juanita J. Rainey, Jay F. Harriman, and Rick G. Schnellmann1 October 2001 | American Journal of Physiology-Renal Physiology, Vol. 281, No. 4Current Concepts in Cell Death1 August 2001 | Current Protocols in Cell Biology, Vol. 11, No. 1Using death to one's advantage: HIV modulation of apoptosisLeukemia, Vol. 15, No. 3Chapter 11 Proteinase families and their inhibitorsThe pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states10 May 2004 | International Journal of Experimental Pathology, Vol. 81, No. 5Nitric oxide inhibits calpain-mediated proteolysis of talin in skeletal muscle cellsTimothy J. Koh, and James G. Tidball1 September 2000 | American Journal of Physiology-Cell Physiology, Vol. 279, No. 3Downregulation of the calpain inhibitor protein calpastatin by caspases during renal ischemia-reperfusionYuexian Shi, Vyacheslav Y. Melnikov, Robert W. Schrier, and Charles L. Edelstein1 September 2000 | American Journal of Physiology-Renal Physiology, Vol. 279, No. 3Noncaspase proteases in apoptosis31 August 2000 | Leukemia, Vol. 14, No. 9Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and DiseaseMartin W. Berchtold, Heinrich Brinkmeier, and Markus Müntener1 July 2000 | Physiological Reviews, Vol. 80, No. 3Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cellsYunchao Su, and Edward R. Block1 June 2000 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 278, No. 6Association of l-arginine transporters with fodrin: implications for hypoxic inhibition of arginine uptakeS. I. Zharikov, and E. R. Block1 January 2000 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 278, No. 1Involvement of gap junctional communication in myogenesisComparison of various calpain inhibitors in reduction of light scattering, protein precipitation and nuclear cataract in vitro2 July 2009 | Current Eye Research, Vol. 21, No. 6Ischemic preconditioning protects the mouse liver by inhibition of apoptosis through a caspase-dependent pathwayHepatology, Vol. 30, No. 5CALPAIN INHIBITION PREVENTS SINUSOIDAL ENDOTHELIAL CELL APOPTOSIS IN THE COLD ISCHEMIC RAT LIVER1,2Transplantation, Vol. 68, No. 1Current Concepts in Cell Toxicity1 May 1999 | Current Protocols in Toxicology, Vol. 00, No. 1Monoclonal Antibodies Directed Against AFAP-110 Recognize Species-Specific and Conserved EpitopesHybridoma, Vol. 18, No. 2Oxidation enhances calpain-induced turbidity in young rat lenses2 July 2009 | Current Eye Research, Vol. 19, No. 1Altered Calpastatin Protein Levels Following Traumatic Brain Injury in RatJournal of Neurotrauma, Vol. 16, No. 1Hypoxia-specific upregulation of calpain activity and gene expression in pulmonary artery endothelial cellsJianliang Zhang, Jawaharlal M. Patel, and Edward R. Block1 September 1998 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 275, No. 3Sinusoidal endothelial cell injury during hepatic preservation and reperfusionHepatology, Vol. 28, No. 2Calpain Mediates Eukaryotic Initiation Factor 4G Degradation during Global Brain Ischemia31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 18, No. 8Calpain-mediated proteolysis of GluR1 subunits in organotypic hippocampal cultures following kainic acid treatmentBrain Research, Vol. 781, No. 1-2Lp82 calpain during rat lens maturation and cataract formation2 July 2009 | Current Eye Research, Vol. 17, No. 11Six-Hour Window of Opportunity for Calpain Inhibition in Focal Cerebral Ischemia in RatsStroke, Vol. 29, No. 1Erythrocyte calpain activity and left ventricular mass in essential hypertensionJournal of Hypertension, Vol. 15, No. 12Modulatory effects of PKC activity on increased 92-kDa gelatinase secretion by neonatal alveolar macrophagesChristophe Delacourt, Patricia Rouet-Benzineb, Christophe Delclaux, Jeannique L’Hour, Alain Harf, and Chantal Lafuma1 November 1997 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 273, No. 5E64d, a membrane-permeable cysteine protease inhibitor, attenuates the effects of parathyroid hormone on osteoblasts in vitroMetabolism, Vol. 46, No. 9Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changesNature Structural Biology, Vol. 4, No. 7Acidic conditions ameliorate both adenosine triphosphate depletion and the development of hyperpermeability in cultured Caco-2BBe enterocytic monolayers subjected to metabolic inhibitionSurgery, Vol. 121, No. 6m-Calpain Activation/Depletion is Associated With Androgen-Induced Reduction of Protein Kinase C and Proliferation of Male Accessory Sex Organ Smooth Muscles CellsThe Journal of UrologyExpression, Subcellular Distribution and Response to Phorbol Esters of Protein Kinase C (PKC) Isozymes in Drug-Sensitive and Multidrug-Resistant KB Cells Evidence for Altered Regulation of PKC-alphaEuropean Journal of Biochemistry, Vol. 239, No. 3Ether lipidwinduced cell damage of neuroblastoma cells is only weakly correlated with increased intracellular Ca2+ levelsCell Calcium, Vol. 19, No. 5Role of Calcium-Activated Neutral Protease (Calpain) in Cell Death in Cultured Neonatal Rat Cardiomyocytes During Metabolic InhibitionCirculation Research, Vol. 76, No. 6Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2ACell, Vol. 81, No. 1Parathyroid hormone—Induced retraction of MC3T3-E1 osteoblastic cells is attenuated by the calpain inhibitor N-Ac-Leu-Leu-NorleucinalMetabolism, Vol. 44, No. 2Calpain inhibition: an overview of its therapeutic potentialTrends in Pharmacological Sciences, Vol. 15, No. 11Neuromuscular contacts of expanded motor units in rat soleus muscles are rescued by leupeptinNeuroscience, Vol. 63, No. 1Transient ischemia causes a reduction of Mg2+ blockade of NMDA receptorsNeuroscience Letters, Vol. 173, No. 1-2Localization of mRNAs for calpain and calpastatin in the adult rat brain by in situ hybridization histochemistryMolecular Brain Research, Vol. 23, No. 1-2Concurrent identification of calpains I and II from chicken skeletal muscleComparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 107, No. 4Modelling post-mortem tenderisation—V: Inactivation of calpainsMeat Science, Vol. 37, No. 3Upregulation of calpain activity in neonatal rat brain after hypoxic-ischemiaBrain Research, Vol. 630, No. 1-2Molecular cloning and bacterial expression of cDNA for rat calpain II 80 kDa subunitBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, Vol. 1216, No. 1A variety of calpain/calpastatin systems in mammalian erythrocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1178, No. 2Activity-dependent interactions between motoneurones and muscles: Their role in the development of the motor unitProgress in Neurobiology, Vol. 41, No. 1Immunohistochemical localization of calpains and calpastatin in the rabbit eyeBrain Research, Vol. 611, No. 2Characterization of Ca2+-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoniBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1181, No. 1Evidence for fibronectin degradation by calpain IIBiochimie, Vol. 75, No. 10Effect of genotype and nutrition on calpastatin inhibitory activity and mRNA abundance in milk-fed lambsBiochimie, Vol. 75, No. 10Cadiac and skeletal muscle enzymes levels in hypertensive and ageing ratsComparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 104, No. 1Purification and autolytic degradation of a calpain-like calcium-dependent proteinase from lobster (Homarus americanus) striated muscleComparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 104, No. 1Differential effects of aluminum ion on smooth muscle calpain I and calpain II activitiesInternational Journal of Biochemistry, Vol. 24, No. 11ProteasesCurrent Opinion in Structural Biology, Vol. 2, No. 5Transcriptional regulation of calcium-activated neutral protease in cardiomyocytes of hypertensive ratsCardiovascular Pathology, Vol. 1, No. 3Polyclonal antisera specific for the proenzyme form of each calpainBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1121, No. 1-2Multiple forms of rat calpastatin cDNA in the coding region of functionally unknown amino-terminal domainBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, Vol. 1129, No. 2Molecular cloning and sequence analysis of a calcium-activated neutral protease (calpain) from Schistosoma mansoniMolecular and Biochemical Parasitology, Vol. 49, No. 2 More from this issue > Volume 71Issue 3July 1991Pages 813-47 Copyright & PermissionsCopyright © 1991 by American Physiological Societyhttps://doi.org/10.1152/physrev.1991.71.3.813PubMed2057527History Published online 1 July 1991 Published in print 1 July 1991 Metrics
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