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A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

2016; American Association for the Advancement of Science; Volume: 351; Issue: 6272 Linguagem: Inglês

10.1126/science.aad2197

1095-9203

Charles K. Kaufman, Christian Mosimann, Zi Peng Fan, Song Yang, Andrew Thomas, Julien Ablain, Justin L. Tan, Rachel Fogley, Ellen van Rooijen, Elliott J. Hagedorn, Christie Ciarlo, Richard M. White, Dominick A. Matos, Ann‐Christin Puller, Cristina Santoriello, Eric C. Liao, Richard A. Young, Leonard I. Zon,

Zebrafish Biomedical Research Applications

Visualizing the beginnings of melanoma In cancer biology, a tumor begins from a single cell within a group of precancerous cells that share genetic mutations. Kaufman et al. used a zebrafish melanoma model to visualize cancer initiation (see the Perspective by Boumahdi and Blanpain). They used a fluorescent reporter that specifically lit up neural crest progenitors that are only present during embryogenesis or during adult melanoma tumor formation. The appearance of this tumor correlated with a set of gene regulatory elements, called super-enhancers, whose identification and manipulation may prove beneficial in detecting and preventing melanoma initiation. Science , this issue p. 10.1126/science.aad2197 ; see also p. 453