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Cortical gray matter volume deficit in patients with first-episode schizophrenia

1996; American Psychiatric Association; Volume: 153; Issue: 12 Linguagem: Inglês

10.1176/ajp.153.12.1548

1535-7228

Kelvin O. Lim, William P. Tew, Michael Kushner, Ka Ming Chow, Brian Matsumoto, Lynn E. DeLisi,

Schizophrenia research and treatment

Back to table of contents Previous article Next article No AccessCortical gray matter volume deficit in patients with first-episode schizophreniaPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.153.12.1548AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: A cortical gray matter deficit has been found in cross- sectional studies of patients with chronic schizophrenia. The purpose of this study was to examine whether this deficit is present early in the course of illness. METHOD: The authors measured cortical gray matter volume on magnetic resonance images acquired within 6 months of onset of illness from 22 patients with first-episode schizophrenia and 51 age-matched comparison subjects from the Stony Brook First Episode Study. RESULTS: A significant cortical gray matter deficit and lateral ventricular enlargement were found in schizophrenic patients relative to the comparison group. CONCLUSIONS: The presence of the cortical gray matter deficit close to onset of illness supports the role of preexisting structural brain deficits in the genesis of schizophrenia. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. 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