Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

2016; Springer Science+Business Media; Volume: 308; Issue: 3 Linguagem: Inglês

10.1007/s00403-016-1625-z

1432-069X

Maria Luiza Diniz de Sousa Lopes, Denise Hélen Imaculada Pereira de Oliveira, Dmitry José de Santana Sarmento, Lélia María Guedes Queiroz, Márcia Cristina da Costa Miguel, Éricka Janine Dantas da Silveira,

Infectious Diseases and Mycology

This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson's correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (p > 0.05). Immunoexpression of p53 was higher in SCC than in AC (p < 0.001), while p21 expression was more observed in AC when compared to SCC group (p = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (r = −0.30, p = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.