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Waterborne Risperidone Decreases Stress Response in Zebrafish

2015; Public Library of Science; Volume: 10; Issue: 10 Linguagem: Inglês

10.1371/journal.pone.0140800

1932-6203

Renan Idalêncio, Fabiana Kalichak, João Gabriel Santos Rosa, Tiago Acosta de Oliveira, Gessi Koakoski, Darlan Gusso, Murilo S. de Abreu, Ana C.V.V. Giacomini, Heloísa Helena de Alcântara Barcellos, Ângelo Piato, Leonardo José Gil Barcellos,

Fish Ecology and Management Studies

The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.