STUDIES ON GOSSYPOL
1928; Elsevier BV; Volume: 77; Issue: 1 Linguagem: Inglês
10.1016/s0021-9258(18)84043-1
ISSN1083-351X
Autores ResumoAttempts to obtain information concerning the nature of the structure of gossypol have been limited to the experiments of Carruth (1).This investigator studied the effects of alkali fusion and several oxidizing agents upon gossypol but did not succeed in obtaining any pure crystalline derivatives or other evidence of a clarifying character.One of the methods used in this laboratory for studying the nature of the gossypol molecule has been to investigate the effects of oxidizing reagents upon the substance.The results as a whole have been more or less discouraging, for with most reagents and methods tried either nothing at all or only amorphous or tarry products having no tendency to crystallize were obtained.With potassium permanganate, however, conditions were found which yielded certain products that have a significant bearing upon at least one phase of the problem.In these experiments gossypol dissolved in slightly more than 2 mols of sodium hydroxide was treated at 0" with potassium permanganate in the proportions of 1 part of gossypol to 5 parts of permanganate.The reaction was quite energetic and terminated in a short time.The manganese dioxide formed was removed by filtration, and the filtrate was made acid with sulfuric acid.In addition to the evolution of carbon dioxide there was evidence of the presence of volatile fatty acids in the reaction mixture.The solution was therefore steamdistilled, and the distillate was examined by the method of Dyer
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