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MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42

2016; Elsevier BV; Volume: 472; Issue: 1 Linguagem: Inglês

10.1016/j.bbrc.2016.02.102

1090-2104

Jinjiang Chou, Bingyu Wang, Tianjing Zheng, Xiaoman Li, Lufeng Zheng, Jinhang Hu, Yan Zhang, Yingying Xing, Tao Xi,

RNA Research and Splicing

Competitive endogenous messenger RNAs (ceRNAs) affect other RNAs transcription through competitively binding common microRNAs (miRNAs). In this study we identified long non-coding RNA (lncRNA) MALAT1 can function as a ceRNA of cell division cycle 42 (cdc42) 3′UTR in inducing migration and invasion of breast cancer cells via miR-1. We found that miR-1 bound both MALAT1 and cdc42 3′UTR directly. Further study showed that MALAT1 induced migration and invasion of breast cancer cells while reduced the level of cdc42. Our results suggest that MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively.