Effects of tenoxicam on nociceptive thalamic neuronal firing in arthritic rats.
1987; National Institutes of Health; Volume: 13; Issue: 7 Linguagem: Inglês
Autores
Braga Pc, Gabriele E. M. Biella, M Tiengo,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoThe antinociceptive action of tenoxicam, a new non-steroidal anti-inflammatory drug, has been investigated by exploring the spontaneous and evoked electrophysiological patterns of firing of thalamic neurons in arthritic rats. A marked decrease in the firing activity evoked by ankle mobilization has been found to be present at doses of tenoxicam of 0.6 mg/kg i.v. A similar effect is obtainable with aspirin (as reference drug) but with doses of 54 mg/kg i.v. On studying the effects of increasing doses of tenoxicam a progressively longer time-course inhibition has been found and the analysis confirmed a linear correlation. Findings are discussed postulating that the final antinociceptive effect of tenoxicam can be correlated with its anti-inflammatory activity.
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