ABILITY OF VARIOUS STEROIDS TO PRODUCE "INFARCTOID CARDIOPATHY" IN RATS CONDITIONED BY NaH2PO4
1958; American Society for Pharmacology and Experimental Therapeutics; Volume: 122; Issue: 4 Linguagem: Inglês
10.1016/s0022-3565(25)12008-9
ISSN1521-0103
AutoresHans Selye, S. Renaud, M Nadasdi,
Tópico(s)Nitric Oxide and Endothelin Effects
ResumoExperiments on rats indicate that infarct-like, massive, myocardial necrosis can be regularly produced by treatment with a variety of steroid hormones, if these substances are administered simultaneously with an excess of NaH 2 PO 4 . Among nineteen steroids examined, 2α-methyl-9α-chlorocortisol acetate proved to be most potent in this respect, although 2α-methyl-9α-fluorocortisol acetate and the two corresponding nonmethylated halogenated corticoids were likewise highly effective. Although some of the corticoids aggravated the nephrocalcinosis that is normally produced by excessive amounts of NaH 2 PO 4 , there was no close relationship between the degree of the myocardial necrosis and of the nephrocalcinosis in the present experimental series. In rats simultaneously treated with ACTH and NaH2PO4, myocardial necrosis likewise occurred, presumably under the influence of endogenous, natural corticoids.
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