Proteínas de choque térmico en la cardioprotección del consumo moderado regular de alcohol
2016; Elsevier BV; Volume: 146; Issue: 7 Linguagem: Inglês
10.1016/j.medcli.2015.12.011
ISSN1578-8989
Autores Tópico(s)Adipose Tissue and Metabolism
ResumoTo study whether the cardioprotective effect of regular alcohol consumption can be explained by the heat shock proteins (HSP), given their pathogenic role in atherosclerosis.Cross-sectional epidemiological study on 452 men and women aged 40-60. Clinical history, epidemiological survey (frequency of average alcohol consumption) and biochemical analysis was performed; Task Force Chart was applied for classification according to the risk of vascular disease. Intracellular HSPA1A, circulating HSPA1A and HSPD1, and anti-Hsp70/anti-Hsp60 antibodies were quantified by ELISA.Two hundred and thirty-eight (52.7%) were abstemious or drank 60 g/d (5.5%). Two hundred and thirty-nine had no vascular risk (VR) factor or a risk 60 g/d especially in subjects with moderate VR, and female drinkers of 40-60 g/d.The cardioprotective effect of 40-60 g/d of alcohol consumption could be due in part, to increased intracellular HSPA1A, a potent anti-inflammatory protein. Excessive intake of alcohol increases antibodies anti-Hsp60, stimulating proinflammatory cytokines. This fact may explain the mortality from cardiovascular disease in heavy drinkers. The clinical application of antibody anti-Hsps quantification has been proposed in patients at risk in order to detect atherosclerotic disease.
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