Menstrual Blood Quantitation in the Rhesus Monkey: An Experimental Tool for Improving Intrauterine Contraceptive Devices (IUDS)
1972; Elsevier BV; Volume: 23; Issue: 4 Linguagem: Inglês
10.1016/s0015-0282(16)38883-5
ISSN1556-5653
AutoresS.T. Shaw, Samir El-Sahwi, D.L. Moyer,
Tópico(s)Ovarian function and disorders
Resumo6 normally menstruating and 21 ovariectomized rhesus monkeys were used to measure the menstrual blood loss (MBL) during an estrous cycle. A reliable method of quantitating MBL should provide better evaluation of the bleeding problem associated with IUDs. The technic used in measuring the MBL and the volume of MBL are presented. The ovariectomized animals were given 25-mcg estradiol im daily for 22 consecutive days of each month and 1.5-mg progesterone daily during the second half of the injection schedule. These injections supported normal endometrial histology. Intravaginal pads were used for the collection of the menstrual blood. MBL was calculated by the Hallberg-Nillson method. Average MBL for all menstrual periods was 2.01 ml. This should provide a necessary parameter for evaluation of IUD-associated uterine hemorrhage.
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