Produção Nacional
Revisado por pares
Booster dose after 10 years is recommended following 17DD-YF primary vaccination
2015; Taylor & Francis; Volume: 12; Issue: 2 Linguagem: Inglês
10.1080/21645515.2015.1082693
ISSN2164-554X
AutoresAna Carolina Campi‐Azevedo, Christiane Costa-Pereira, Lis Ribeiro do Valle Antonelli, Cristina Toscano Fonseca, Andréa Teixeira‐Carvalho, Gabriela Villela-Rezende, Raiany A. Santos, Maurício Azevedo Batista, Fernanda M.F. Campos, Luiza Pacheco-Porto, Otoni A Melo Júnior, Débora MSH Hossell, Jordana Grazziela Coelho-dos-Reis, Vanessa Peruhype-Magalhães, Matheus Fernandes Costa-Silva, Jaquelline Germano de Oliveira, Roberto Farias, Tatiana Guimarães de Noronha, Jandira Aparecida Lemos, Vanessa dos Reis von Doellinger, Marisol Simões, Mirian M de Souza, Luiz CC Malaquias, Harold Richard Persi, Jorge Marcelo Pereira, José A Martins, Marcos Dornelas-Ribeiro, Aline de A Vinhas, Tatiane R Alves, Maria de Lourdes de Sousa Maia, Marcos da Silva Freire, Reinaldo de Menezes Martins, Akira Homma, Alessandro Romano, Carla Magda Allan Santos Domingues, Pedro Luíz Tauil, Pedro Fernando da Costa Vasconcelos, María Rios, Iramaya Rodrigues Caldas, Luiz Antônio Bastos Camacho, Olindo Assis Martins‐Filho,
Tópico(s)Viral Infections and Vectors
ResumoA single vaccination of Yellow Fever vaccines is believed to confer life-long protection. In this study, results of vaccinees who received a single dose of 17DD-YF immunization followed over 10 y challenge this premise. YF-neutralizing antibodies, subsets of memory T and B cells as well as cytokine-producing lymphocytes were evaluated in groups of adults before (NVday0) and after (PVday30-45, PVyear1-4, PVyear5-9, PVyear10-11, PVyear12-13) 17DD-YF primary vaccination. YF-neutralizing antibodies decrease significantly from PVyear1-4 to PVyear12-13 as compared to PVday30-45, and the seropositivity rates (PRNT≥2.9Log10mIU/mL) become critical (lower than 90%) beyond PVyear5-9. YF-specific memory phenotypes (effector T-cells and classical B-cells) significantly increase at PVday30-45 as compared to naïve baseline. Moreover, these phenotypes tend to decrease at PVyear10-11 as compared to PVday30-45. Decreasing levels of TNF-α+ and IFN-γ+ produced by CD4+ and CD8+ T-cells along with increasing levels of IL-10+CD4+T-cells were characteristic of anti-YF response over time. Systems biology profiling represented by hierarchic networks revealed that while the naïve baseline is characterized by independent micro-nets, primary vaccinees displayed an imbricate network with essential role of central and effector CD8+ memory T-cell responses. Any putative limitations of this cross-sectional study will certainly be answered by the ongoing longitudinal population-based investigation. Overall, our data support the current Brazilian national immunization policy guidelines that recommend one booster dose 10 y after primary 17DD-YF vaccination.
Referência(s)