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Control of Genome Integrity in Terminally Differentiating and Postmitotic Aging Cells

1980; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-540-38267-6_23

1861-0412

Sohan P. Modak, Claudia UNGER‐ULLMANN,

CRISPR and Genetic Engineering

During early morphogenesis, organ- or tissue-specific “stem” cell lines are established. Initially multipotent, the progeny become committed to the expression of an increasingly restricted number of specialized phenotypes. The process leading to acquisition by cells of specialized structures and/or functions is called cell differentiation. Implicit in such a process is the progressive loss of the potential for tissue metaplasia, i.e., the ability to be reprogramed and converted into another phenotype. A rare exception to this rule in vertebrates is the Wolffian lens regeneration in lentectomized newts where fully differentiated melanocytes from the dorsal iris dedifferentiate, proliferate and then redifferentiate into lens fiber cells (Yamada 1977).