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Effect of bio-template on the properties of SiO2/Al2O3 composites for drug delivery

2016; Elsevier BV; Volume: 37; Linguagem: Inglês

10.1016/j.jiec.2016.02.012

1876-794X

Long‐Yue Meng, Weiqi Jiang, Wenxiang Piao, Wan Meng,

Aluminum Alloys Composites Properties

In this study, SiO2/Al2O3 composites (C-SLNs) were successfully synthesized using chitosan as the template for drug delivery. The C-SLNs had higher specific surface areas (244–607 m2/g), total pore volumes (0.19–0.34 cm3 g−1), and narrow mesopore size distribution. The porosity of the C-SLNs prepared under high Si/Al ratio conditions was achieved mostly by the formation of wider pores that were distributed in the meso-/macro-pores. And, the C-SLNs were used as a levofloxacin carrier to study its drug release behavior, which exhibited an initial fast release followed by a sustained release and antibacterial effectiveness over a long period.