Tracer Studies of Potential Radiosensitizing Agents
1956; Springer Nature; Volume: 10; Issue: 4 Linguagem: Inglês
10.1038/bjc.1956.90
ISSN1532-1827
AutoresD.H. Marrian, Donald R. Maxwell,
Tópico(s)Radiation Effects and Dosimetry
ResumoTHIS paper continues our studies (Marrian and Maxwell, 1956) of potential radiosensitizers, compounds which, it is hoped, might selectively concentrate in fast growing tissues and there accentuate the effects of ionising radiations.There are good reasons for believing that tetrasodium 2-methyl-I: 4-naphthohydroquinone diphosphate (Synkavit) (I) can accumulate in tumour tissue for short periods after intravenous injection (Mitchell, 1955; Marrian and Maxwell, 1956) and we felt that related compounds carrying a y-emitting isotope might combine radio-sensitization with, possibly, a useful dose of localised radiation.82Br and 1311 seemed the most useful isotopes for this purpose and this paper records some observations on the metabolism of tetrasodium 2-methyl-3-82Br-bromo-I: 4-naphthohydroquinone diphosphate (II) and also of 2: 3-dimethyl-5: 6-di-1311- iodo-I: 4-benzohydroquinone diphosphate (III).The antimitotic properties of the former compound have been established (Friedmann, Marrian and Simon- Reuss, 1952) and although the latter is inactive by the same test (Simon-Reuss, unpublished) it seems to be one of the few hydroquinone diphosphates in which labelling with 1311 is simple.Studies of its metabolism were therefore worth- while, and served to confirm the lability of halogen in a substituted hydroquinone ring.
Referência(s)