Tuberculosis or sarcoidosis: Opposite ends of the same disease spectrum?
2016; Elsevier BV; Volume: 98; Linguagem: Inglês
10.1016/j.tube.2016.01.003
ISSN1873-281X
AutoresRupesh Agrawal, Ae Ra Kee, Leslie Ang, Yeo Tun Hang, Vishali Gupta, Onn Min Kon, Donald Mitchell, Manfred Zierhut, Carlos Pavésio,
Tópico(s)Tuberculosis Research and Epidemiology
ResumoTuberculosis and sarcoidosis are chronic systemic diseases that have similar pulmonary and extra-pulmonary manifestations. Multiple studies have found an epidemiological, molecular, and immunological link between the two. It has been suggested that mycobacterium tuberculosis could be a common pathophysiologic mechanism for tuberculosis and sarcoidosis, and that both clinical entities can trigger similar immunological response in patients. Due to this close association, together with possible coexistence in the same patient, the diagnosis of one disease from another may be difficult. In our paper, we suggest that tuberculosis and sarcoidosis are two ends of the same spectrum. Given the pathophysiological and clinical link between the two, we also propose a classification system for tuberculosis and sarcoidosis: Sarcoidosis (S); Sarcoid-Tuberculous (ST); Tuberculous Sarcoid (TS) and Tuberculosis (TB). More research and clinical trials should first be done to affirm the link between the two disease entities.
Referência(s)