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BIBTEX RIS

Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease

2015; Sociedade Brasileira de Cardiologia (SBC); Linguagem: Inglês

10.5935/abc.20150105

ISSN

1678-4170

Autores

Gabriela da Silva Cruz, Ana Luiza Dias Ângelo, Ticiana Ferreira Larocca, Carolina Thé Macêdo, Márcia Noya-Rabelo, Luís Cláudio Lemos Correia, Jorge Andion Torreão, Bruno Solano de Freitas Souza, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares,

Tópico(s)

Protein Tyrosine Phosphatases

Resumo

Background: Galectin-3, a β-galactoside binding lectin, has been described as a mediator of cardiac fibrosis in experimental studies and as a risk factor associated with cardiovascular events in subjects with heart failure.Previous studies have evaluated the genetic susceptibility to Chagas disease in humans, including the polymorphisms of cytokine genes, demonstrating correlations between the genetic polymorphism and cardiomyopathy development in the chronic phase.However, the relationship between the galectin-3 single nucleotide polymorphism (SNP) and phenotypic variations in Chagas disease has not been evaluated. Objective: The present study aimed to determine whether genetic polymorphisms of galectin-3 may predispose to the development of cardiac forms of Chagas disease.Methods: Fifty-five subjects with Chagas disease were enrolled in this observational study.Real-time polymerase chain reaction (PCR) was used for genotyping the variants rs4644 and rs4652 of the galectin-3 gene.Results: For the SNP rs4644, the relative risk for the cardiac form was not associated with the genotypes AA (OR = 0.79, p = 0.759), AC (OR = 4.38, p = 0.058), or CC (OR = 0.39, p = 0.127).Similarly, for the SNP rs4652, no association was found between the genotypes AA (OR = 0.64, p = 0.571), AC (OR = 2.85, p = 0.105), or CC (OR = 0.49, p = 0.227) and the cardiac form of the disease.Conclusion: Our results showed no association between the different genotypes for both SNPs of the galectin-3 gene and the cardiac form of Chagas disease.(

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