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Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

2016; Elsevier BV; Volume: 6; Linguagem: Inglês

10.1016/j.dib.2016.01.017

2352-3409

Mariana Conceição, Liliana Mendonça, Clévio Nóbrega, Célia Gomes, Pedro M. Costa, Hirokazu Hirai, João Nuno Moreira, Maria C. Pedroso de Lima, N. Manjunath, Luís Pereira de Almeida,

Toxoplasma gondii Research Studies

In a clinical setting, where multiple administrations of the therapeutic agent are usually required to improve the therapeutic outcome, it is crucial to assess the immunogenicity of the administered nanoparticles. In this data work, we investigated the safety profile of the repeated intravenous administration of brain-targeted stable nucleic acid lipid particles (RVG-9r-targeted SNALPs). To evaluate local activation of the immune system, we performed analysis of mouse tissue homogenates and sections from cerebellum. To investigate peripheral activation of the immune system, we used serum of mice that were intravenously injected with RVG-9r-targeted SNALPs. These data are related and were discussed in the accompanying research article entitled "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado–Joseph disease neurological phenotype" (Conceição et al., in press) [1].