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BIBTEX RIS

Detection of dengue NS1 and NS3 proteins in placenta and umbilical cord in fetal and maternal death

2016; Wiley; Volume: 88; Issue: 8 Linguagem: Inglês

10.1002/jmv.24479

ISSN

1096-9071

Autores

Priscila Conrado Guerra Nunes, Marciano Viana Paes, Carlos Alberto Basílio de Oliveira, Ana Carla Gomes Soares, Ana María Bispo de Filippis, Monique da Rocha Queiroz Lima, Ada Maria de Barcelos Alves, Juliana Fernandes Amorim da Silva, Janice Mery Chicarino de Oliveira Coelho, Francisco das Chagas de Carvalho Rodrigues, Rita Maria Ribeiro Nogueira, Flávia Barreto dos Santos,

Tópico(s)

Dengue and Mosquito Control Research

Resumo

In Brazil, dengue is a public health problem with the occurrence of explosive epidemics. This study reports maternal and fetal deaths due to dengue and which tissues of placenta and umbilical cord were analyzed by molecular methods and immunohistochemistry. The dengue NS3 and NS1 detection revealed the viral presence in different cells from placenta and umbilical cord. In the latter, DENV-2 was detected at a viral titer of 1,02 × 10(4) amounts of viral RNA. It was shown that the DENV markers analyzed here may be an alternative approach for dengue fatal cases investigation, especially involving maternal and fetal death. J. Med. Virol. 88:1448-1452, 2016. © 2016 Wiley Periodicals, Inc.

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