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BIBTEX RIS

Mycobacterium leprae DNA Associated with Type 1 Reactions in Single Lesion Paucibacillary Leprosy Treated with Single Dose Rifampin, Ofloxacin, and Minocycline

2007; American Society of Tropical Medicine and Hygiene; Volume: 77; Issue: 5 Linguagem: Inglês

10.4269/ajtmh.2007.77.829

ISSN

1476-1645

Autores

Ana Lúcia Osório Maroclo de Sousa, Mariane M. A. Stefani, Gisner A. S. Pereira, Maurício Barcelos Costa, Paula Frassinetti Bessa Rebello, Maria Kátia Gomes, Kazuê Narahashi, Thomas P. Gillis, James L. Krahenbuhl, Celina Maria Turchi Martelli,

Tópico(s)

Infectious Diseases and Tuberculosis

Resumo

Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities. Single skin lesion paucibacillary leprosy volunteers (N = 135) recruited in three Brazilian endemic regions, treated with single-dose rifampin, ofloxacin, and minocycline (ROM), were monitored for 3 years. Poor outcome was defined as type 1 reactions with or without neuritis. IgM anti-phenolic glycolipid I, histopathology, Mitsuda test, and Mycobacterium leprae DNA polymerase chain reaction (ML-PCR) were performed at baseline. chi(2) test, Kaplan-Meir curves, and Cox proportional hazards were applied. The majority of volunteers were adults with a mean age of 30.5 +/- 15.4 years; 44.4% were ML-PCR positive. During follow-up, 14.8% of the patients had a poor clinical outcome, classified as a type 1 reaction. Older age (> or = 40 years), ML-PCR positivity, and lesion size > 5 cm were associated with increased risk. In multivariate analysis, age (> or = 40 years) and ML-PCR positivity remained baseline predictors of type 1 reaction among monolesion leprosy patients.

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