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Prediction of Tumor Radiosensitivity by Hexafluoromisonidazole Retention Monitored by [ 1 H]/[ 19 F] Magnetic Resonance Spectroscopy

1991; Pergamon Press; Volume: 3; Issue: 5 Linguagem: Inglês

10.3727/095535491820873353

0955-3541

Shi‐Jiang Li, Guan‐Yuan Jin, John E. Moulder,

MRI in cancer diagnosis

Hexafluoromisonidazole (CCI-103F) is a hypoxic cell label that can be measured by in vivo [1H]/[19F] magnetic resonance spectroscopy (MRS). The retention of CCI-103F in SCCVII tumors was found to be correlated with tumor size, with larger tumors retaining more label. Such a correlation was anticipated, as larger SCCVII tumors have larger hypoxic fractions. A significant but less strong correlation was also found between CCI-103F retention and the fraction of tumor cells surviving after 10 Gy irradiation, with tumors that retained larger amounts of CCI-103F having higher surviving fractions. These results indicated that non-invasive MRS measurement of CCI-103F retention could predict radiosensitivity in SCCVII tumors. The lack of a strong correlation between CCI-103F retention and radiosensitivity, however, indicated that hypoxic fraction was not the only factor influencing radiosensitivity in these tumors.