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d ‐Allulose supplementation normalized the body weight and fat‐pad mass in diet‐induced obese mice via the regulation of lipid metabolism under isocaloric fed condition

2016; Wiley; Volume: 60; Issue: 7 Linguagem: Inglês

10.1002/mnfr.201500771

1613-4133

Youngji Han, Hye Jin Han, Ae‐Hyang Kim, Ji‐Young Choi, Su‐Jung Cho, Yong Bok Park, Un Ju Jung, Myung‐Sook Choi,

Liver Disease Diagnosis and Treatment

Scope A number of findings suggest that zero‐calorie d ‐allulose, also known as d ‐psicose, has beneficial effects on obesity‐related metabolic disturbances. However, it is unclear whether d ‐allulose can normalize the metabolic status of diet‐induced obesity without having an impact on the energy density. We investigated whether 5% d ‐allulose supplementation in a high fat diet(HFD) could normalize body fat in a diet‐induced obesity animal model under isocaloric pair‐fed conditions. Methods and results Mice were fed an HFD with or without various sugar substitutes ( d ‐glucose, d ‐fructose, erytritol, or d ‐allulose, n = 10 per group) for 16 wk. Body weight and fat‐pad mass in the d ‐allulose group were dramatically lowered to that of the normal group with a simultaneous decrease in plasma leptin and resistin concentrations. d ‐allulose lowered plasma and hepatic lipids while elevating fecal lipids with a decrease in mRNA expression of CD36, ApoB48, FATP4, in the small intestine in mice. In the liver, activities of both fatty acid synthase and β‐oxidation were downregulated by d ‐allulose to that of the normal group; however, in WAT, fatty acid synthase was decreased while β‐oxidation activity was enhanced. Conclusion Taken together, our findings suggest that 5% dietary d ‐allulose led to the normalization of the metabolic status of diet‐induced obesity by altering lipid‐regulating enzyme activities and their gene‐expression level along with fecal lipids.