Artigo Acesso aberto Revisado por pares

Predicting clinical outcome from reward circuitry function and white matter structure in behaviorally and emotionally dysregulated youth

2016; Springer Nature; Volume: 21; Issue: 9 Linguagem: Inglês

10.1038/mp.2016.5

ISSN

1476-5578

Autores

Michele A. Bertocci, Genna Bebko, Amelia Versace, Jay C. Fournier, Satish Iyengar, Thomas M. Olino, Lisa Bonar, Jorge Almeida, Susan B. Perlman, Claudiu Schirda, Michael J. Travis, Mary Kay Gill, Vaibhav A. Diwadkar, Erika E. Forbes, Jeffrey L. Sunshine, Scott K. Holland, R. A. Kowatch, Boris Birmaher, David Axelson, Sarah McCue Horwitz, Thomas Frazier, L. Eugene Arnold, Mary A. Fristad, Eric A. Youngstrom, Robert L. Findling, Mary L. Phillips,

Tópico(s)

Functional Brain Connectivity Studies

Resumo

Behavioral and emotional dysregulation in childhood may be understood as prodromal to adult psychopathology. Additionally, there is a critical need to identify biomarkers reflecting underlying neuropathological processes that predict clinical/behavioral outcomes in youth. We aimed to identify such biomarkers in youth with behavioral and emotional dysregulation in the Longitudinal Assessment of Manic Symptoms (LAMS) study. We examined neuroimaging measures of function and white matter in the whole brain using 80 youth aged 14.0 (s.d.=2.0) from three clinical sites. Linear regression using the LASSO (Least Absolute Shrinkage and Selection Operator) method for variable selection was used to predict severity of future behavioral and emotional dysregulation measured by the Parent General Behavior Inventory-10 Item Mania Scale (PGBI-10M)) at a mean of 14.2 months follow-up after neuroimaging assessment. Neuroimaging measures, together with near-scan PGBI-10M, a score of manic behaviors, depressive behaviors and sex, explained 28% of the variance in follow-up PGBI-10M. Neuroimaging measures alone, after accounting for other identified predictors, explained ~1/3 of the explained variance, in follow-up PGBI-10M. Specifically, greater bilateral cingulum length predicted lower PGBI-10M at follow-up. Greater functional connectivity in parietal-subcortical reward circuitry predicted greater PGBI-10M at follow-up. For the first time, data suggest that multimodal neuroimaging measures of underlying neuropathologic processes account for over a third of the explained variance in clinical outcome in a large sample of behaviorally and emotionally dysregulated youth. This may be an important first step toward identifying neurobiological measures with the potential to act as novel targets for early detection and future therapeutic interventions.

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