Positive Allosteric Modulators for γ-Aminobutyric Acid B Receptors Open New Routes for the Development of Drugs Targeting Family 3 G-Protein-Coupled Receptors
2001; American Society for Pharmacology and Experimental Therapeutics; Volume: 60; Issue: 5 Linguagem: Inglês
10.1124/mol.60.5.881
ISSN1521-0111
AutoresJean‐Philippe Pin, Marie‐Laure Parmentier, Laurent Prézeau,
Tópico(s)Biochemical effects in animals
ResumoThe main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA), activates two types of receptors, the GABAA and GABAB receptors. GABAA receptors are ligand-gated chloride channels responsible for the fast inhibitory action of GABA. These receptors are composed of
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