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Inhalation Studies with Chloracetophenone, Diphenylaminochloroarsine, and Pelargonic Morpholide—II. Human Exposures

1962; Taylor & Francis; Volume: 23; Issue: 3 Linguagem: Inglês

10.1080/00028896209342854

2163-369X

Charles L. Punte, Philip J. Gutentag, Edmund J. Owens, Louis E. Gongwer,

Carcinogens and Genotoxicity Assessment

Abstract Human subjects have been exposed to chloracetophenone, diphenylaminochloroarsine, and pelargonic morpholide aerosols in various airborne concentrations below the maximum safe inhaled doses for man as established from animal toxicity determinations. These are 350, 100, and 500 mg-min/M3 for chloracetophenone, diphenylaminochloroarsine, and pelargonic morpholide, respectively. The studies indicate that these compounds are relatively non toxic but are highly irritating to both the eyes and respiratory tract. On the basis of response of the subjects exposed to the airborne concentrations the irritancy index was: pelargonic morpholide> diphenylaminochloroarsine > chloracetophenone. The recovery index was: pelargonic morpholide > chloracetophenone > diphenylaminochloroarsine.