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Epidemiology of acute promyelocytic leukemia in Italy

1991; Elsevier BV; Volume: 2; Issue: 6 Linguagem: Inglês

10.1093/oxfordjournals.annonc.a057974

1569-8041

Giuseppe Avvisati, Andrea Mele, M. A. Stazi, M. L. Vegna, P. Pasquini, Franco Mandelli, Bruno Rotoli, Gennaro De Rosa, Giuseppe Francesco Sferrazza Papa, Adriano Venditti, P Citarrella, M. Tambone Reyes, E Ascari, Roberto William Invernizzi, A Cajozzo, Maurizio Musso, Antonio Alberti, Antonio Peta, P. Rossi Ferrini, Fabiana Leoni, Francesco Paolo Caronia, Salvatore Mirto, Francesco Nobile, P Iacopino, L Resegotti, B Allione, S. Monfardini, Vittorina Zagonel, Vincenzo Liso, Giorgina Specchia, S Tura, Giuseppe Visani, G Broccia, Wilma Deplano, Francesco Ricciuti, Michele Pizzuti, Maurizio Longinotti, Silvana Bonfigli, A. De Laurenzi, L Pacilli, Laura Deriu, Anna Chierichini, B Bizzi, Gemma Leone, R. De Biasi, E. Miraglia, Laurie Bruzzese, Antonio Abbadessa,

Antioxidant Activity and Oxidative Stress

This retrospective epidemiologic study on 256 cases of Acute Promyelocytic Leukemia (APL) observed in 20 Italian hematology centers between 1980 and 1988 demonstrated that APL is different from the other acute non-lymphocytic leukemias (ANLL). The male/female ratio was 0.9; median age at diagnosis was 40 years (with 80% of patients between 15 and 54 years of age). The minimal annual incidence of APL in Italy per 1,000,000 inhabitants was estimated to be 0.6; an increased incidence was observed in spring and in autumn. The overall median survival duration of APL patients was 12.6 months. From an epidemiological point of view APL is a distinctive subtype of ANLL.