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Myocardial Metabolism in Man at Rest and During Prolonged Exercise

1971; Springer Nature; Linguagem: Inglês

10.1007/978-1-4613-4609-8_42

2214-8019

B. W. Lassers, L. Kaijser, Mark L. Wahlqvist, L. A. Carlson,

Cardiac Ischemia and Reperfusion

The technique of coronary sinus catheterisation with measurement of arterio-venous differences across the heart has provided considerable information about the uptake and utilization of plasma substrates by the myocardium in resting man. There is general agreement that in the resting fasting state plasma free fatty acids (FFA) and glucose are the principle substrates for myocardial oxidation with smaller contributions being made by plasma lactate, pyruvate and ketone bodies (1,2,3,4,5,6). However, despite the finding of triglyceride uptake by the isolated animal heart (7,8,9,10,11,12), and the demonstration of the presence of lipoprotein lipase activity in the human heart (13,l1), coronary sinus catheterisation studies in man have failed to demonstrate satisfactorily the uptake of plasma triglycerides by individual hearts.