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High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis

2016; Lippincott Williams & Wilkins; Volume: 195; Issue: 6 Linguagem: Inglês

10.1016/j.juro.2015.12.096

1527-3792

Larissa Alves Afonso, Thaissa Isaias Cordeiro, Fernanda Nahoum Carestiato, Antônio Augusto Ornellas, Gilda Alves, Silvia Maria Baêta Cavalcanti,

Urologic and reproductive health conditions

No AccessJournal of UrologyAdult Urology1 Jun 2016High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis Larissa A. Afonso, Thaissa I. Cordeiro, Fernanda N. Carestiato, Antonio Augusto Ornellas, Gilda Alves, and Sílvia M.B. Cavalcanti Larissa A. AfonsoLarissa A. Afonso Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil , Thaissa I. CordeiroThaissa I. Cordeiro Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil , Fernanda N. CarestiatoFernanda N. Carestiato Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil , Antonio Augusto OrnellasAntonio Augusto Ornellas Department of Urology, Brazilian National Institute of Cancer and Hospital Mário Kröeff, Rio de Janeiro, Brazil , Gilda AlvesGilda Alves Department of Urology, Research Coordination, Brazilian National Institute of Cancer and Circulating Biomarkers Laboratory, Department of Pathology, State University of Rio de Janeiro, Rio de Janeiro, Brazil , and Sílvia M.B. CavalcantiSílvia M.B. Cavalcanti Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil View All Author Informationhttps://doi.org/10.1016/j.juro.2015.12.096AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: There has been increasing interest in understanding the natural history of HPV and the diseases that it causes in men. HPV infection is strongly associated with penile cancer, lack of neonatal circumcision and phimosis. We investigated the incidence of HPV infection in asymptomatic men and patients with phimosis. Materials and Methods: We assessed 110 asymptomatic men and 30 patients who underwent circumcision due to phimosis. DNA was extracted from swabbed samples collected from asymptomatic men and from foreskin samples collected at circumcision. Polymerase chain reaction using consensus primers for detecting HPV-MY09/11 was performed to detect generic HPV DNA. HPV genotyping was done by polymerase chain reaction amplification with primers for the E6 gene DNA sequences HPV6, HPV11, HPV16, HPV18, HPV31, HPV33, HPV35, HPV45 and HPV58. Results: HPV was present in 46.66% of patients with phimosis, of whom 50% had high risk HPV genotypes. Of asymptomatic cases 16.36% were HPV positive but only 1 sample showed high risk HPV. We detected a significantly high rate of HPV genital infection in patients presenting with phimosis compared with asymptomatic men (p = 0.00167). The prevalence of high risk HPV genotypes in patients with phimosis was also statistically significant (p = 0.0004). Conclusions: We found a robust association between phimosis and the genital HPV prevalence in men and a significant frequency of high risk HPV. 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Google Scholar © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byNiederberger C (2019) Re: Infectious Human Papillomavirus Virions in Semen Reduce Clinical Pregnancy Rates in Women Undergoing Intrauterine InseminationJournal of Urology, VOL. 203, NO. 2, (238-238), Online publication date: 1-Feb-2020. Volume 195Issue 6June 2016Page: 1784-1789 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.Keywordscircumcision, malehuman papillomavirus DNA testsphimosispenisinfectionMetricsAuthor Information Larissa A. Afonso Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil More articles by this author Thaissa I. Cordeiro Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil More articles by this author Fernanda N. Carestiato Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil More articles by this author Antonio Augusto Ornellas Department of Urology, Brazilian National Institute of Cancer and Hospital Mário Kröeff, Rio de Janeiro, Brazil More articles by this author Gilda Alves Department of Urology, Research Coordination, Brazilian National Institute of Cancer and Circulating Biomarkers Laboratory, Department of Pathology, State University of Rio de Janeiro, Rio de Janeiro, Brazil More articles by this author Sílvia M.B. Cavalcanti Department of Microbiology and Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil More articles by this author Expand All Advertisement PDF downloadLoading ...