Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value
2016; American Thoracic Society; Volume: 194; Issue: 5 Linguagem: Inglês
10.1164/rccm.201510-2091oc
ISSN1535-4970
AutoresMaha Farhat, Răzvan Sultana, Oleg Iartchouk, Sam Bozeman, James E. Galagan, Peter Sisk, Christian Stolte, Hanna Nebenzahl-Guimaraes, Karen R. Jacobson, Alexander Sloutsky, Davinder Kaur, James E. Posey, Barry N. Kreiswirth, Natalia Kurepina, Leen Rigouts, Elizabeth M. Streicher, Tommie C. Victor, Robin M. Warren, Dick van Soolingen, Megan Murray,
Tópico(s)Diagnosis and treatment of tuberculosis
ResumoThe development of molecular diagnostics that detect both the presence of Mycobacterium tuberculosis in clinical samples and drug resistance-conferring mutations promises to revolutionize patient care and interrupt transmission by ensuring early diagnosis. However, these tools require the identification of genetic determinants of resistance to the full range of antituberculosis drugs.
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