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Disease onset in familial and sporadic multiple sclerosis in Argentina

2016; Elsevier BV; Volume: 6; Linguagem: Inglês

10.1016/j.msard.2016.01.004

2211-0356

Juan Ignacio Rojas, Liliana Patrucco, Jimena Míguez, Vladimiro Sinay, Fátima Pagani Cassara, Fernando Cáceres, Nora Fernández Liguori, Maria Luisa Saladino, Norma Deri, G. Jaacks, Marcela Parada Marcilla, M.I. Arrigoni, Jorge Correale, M. Fiol, María Célica Ysrraelit, Adriana Carrá, María Celeste Curbelo, Alejandra Martínez, Judith Steinberg, Santiago Bestoso, Javier Hryb, José Luis Di Pace, Mónica Perassolo, Edgar Carnero Contentti, Alejandro Caride, Pablo A. López, Cristina Martínez, Edgardo Reich, Edgardo Cristiano,

Systemic Sclerosis and Related Diseases

The present study was carried out to assess if there is an anticipation of age at onset in younger generations of familial multiple sclerosis (FMS) vs. sporadic MS (SMS) in Argentina. Methods: multicenter study that included patients from 14 MS Centers of Argentina. Patients were considered as FMS if they had in their family at least one relative of first or second degree diagnosed with MS; otherwise, patients were considered to have SMS. We compared the age at onset between familial and sporadic cases as well as the age at onset between relatives from different generations in FMS vs. SMS. Results: 1333 patients were included, 97 of them were FMS (7.3%). A lower age at onset in the younger generations of FMS cases was found compared with older generations of FMS as well as. SMS cases (24.1±3.7 years vs. 30.3±5.7 years, and 32.4±9.4 respectively; p<0.001). No differences were observed between older generations of FMS vs. SMS cases (p=0.12). Conclusion: we observed an anticipation of age at onset of MS in younger generations of patients with FMS vs. older generations of FMS and SMS.