NAD + in aging, metabolism, and neurodegeneration
2015; American Association for the Advancement of Science; Volume: 350; Issue: 6265 Linguagem: Inglês
10.1126/science.aac4854
ISSN1095-9203
Autores Tópico(s)Calcium signaling and nucleotide metabolism
ResumoNicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.
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