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Estradiol Benzoate (EB)-Induced Changes in Serum-Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) In Immature Female Rats

1971; Elsevier BV; Volume: 22; Issue: 12 Linguagem: Inglês

10.1016/s0015-0282(16)38643-5

1556-5653

Shao‐Yao Ying, Victor S. Fang, Roy O. Greep,

Hypothalamic control of reproductive hormones

The changes in serum LH and FSH (luteinizing hormone and follicle-stimulating hormone) in immature rats treated with an optimal dose fo estradiol benzoate (EB) were measured by antibody radioimmunoassay. Ovulation occurred 72 hours after EB injection in 87% of the rats and ovarian weights were significantly increased (p<.05) at 48 hours. LH levels rose to a peak 15 nanograms/ml) at 56 hours. Serum FSH drastically increased at 2 hours (4 nanograms/ml) dropped at 24 hours (about 1 nanogram/ml) and rose to a second peak at 56 hours (15-19 nanograms/ml). FSH and LH values were significantly higher (p<.01) at 65 hours after EB injection than at 72 hours after injection. Uterine weight was also significantly increased at 56 hours (180 mg). A surge of gonadotropins including LH and FSH concurrent with physiologic changes in the reproductive tract occurs prior to ovulation in the immature rats pretreated with an optimal dose of EB.