Microarray Expression Analysis for the Paradoxical Roles of Acanthopanax senticosus Harms in Treating α-Synucleinopathies
2015; Wiley; Volume: 30; Issue: 2 Linguagem: Inglês
10.1002/ptr.5522
ISSN1099-1573
AutoresXu‐zhao Li, Shuai‐nan Zhang, Fang Lü, Shumin Liu,
Tópico(s)NF-κB Signaling Pathways
ResumoPhytotherapy ResearchVolume 30, Issue 2 p. 243-252 Research Article Microarray Expression Analysis for the Paradoxical Roles of Acanthopanax senticosus Harms in Treating α-Synucleinopathies Xu-zhao Li, Xu-zhao Li Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, 150040 China Department of Pharmacy, GuiYang College of Traditional Chinese Medicine, GuiYang, 550025 ChinaJoint first authors.Search for more papers by this authorShuai-nan Zhang, Shuai-nan Zhang Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, 150040 ChinaJoint first authors.Search for more papers by this authorFang Lu, Corresponding Author Fang Lu Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, 150040 China Correspondence to: Shu-min Liu, Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, He Ping Road 24, Harbin 150040, China; Fang Lu, Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, He Ping Road 24, Harbin 150040, China. E-mail: keji-liu@163.com (Shu-min Liu); lufang_19790501@163.com (Fang Lu)Search for more papers by this authorShu-min Liu, Corresponding Author Shu-min Liu Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, 150040 China Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin, 150040 China Correspondence to: Shu-min Liu, Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, He Ping Road 24, Harbin 150040, China; Fang Lu, Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, He Ping Road 24, Harbin 150040, China. E-mail: keji-liu@163.com (Shu-min Liu); lufang_19790501@163.com (Fang Lu)Search for more papers by this author Xu-zhao Li, Xu-zhao Li Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, 150040 China Department of Pharmacy, GuiYang College of Traditional Chinese Medicine, GuiYang, 550025 ChinaJoint first authors.Search for more papers by this authorShuai-nan Zhang, Shuai-nan Zhang Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, 150040 ChinaJoint first authors.Search for more papers by this authorFang Lu, Corresponding Author Fang Lu Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, 150040 China Correspondence to: Shu-min Liu, Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, He Ping Road 24, Harbin 150040, China; Fang Lu, Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, He Ping Road 24, Harbin 150040, China. E-mail: keji-liu@163.com (Shu-min Liu); lufang_19790501@163.com (Fang Lu)Search for more papers by this authorShu-min Liu, Corresponding Author Shu-min Liu Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, 150040 China Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin, 150040 China Correspondence to: Shu-min Liu, Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, He Ping Road 24, Harbin 150040, China; Fang Lu, Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, He Ping Road 24, Harbin 150040, China. E-mail: keji-liu@163.com (Shu-min Liu); lufang_19790501@163.com (Fang Lu)Search for more papers by this author First published: 27 November 2015 https://doi.org/10.1002/ptr.5522Citations: 7 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract α-Synuclein is a key player in the pathogenesis of neurodegenerative disorders with Lewy bodies. Our previous studies have also showed that Acanthopanax senticosus harms (AS) could significantly suppress α-synuclein overexpression and toxicity. Identifying the RNAs related to α-synucleinopathies may facilitate understanding the pathogenesis of the diseases and the safe application of AS in the clinic. Microarray expression profiling of long non-coding RNAs (lncRNAs) and mRNAs was undertaken in control non-transgenic and human α-synuclein transgenic mice. The effects of AS on central nervous system (CNS) in pathology and physiology were investigated based on the lncRNA/mRNA targets analysis. In total, 341 lncRNAs and 279 mRNAs were differentially expressed by α-synuclein stimulus, among which 29 lncRNAs and 25 mRNAs were involved in the anti-α-synucleinopathies mechanism of AS. However, the levels of 19/29 lncRNAs and 12/25 mRNAs in AS group were similar to those in α-synuclein group, which may cause potential neurotoxicity analogous to α-synuclein. This study demonstrated that some of lncRNAs/mRNAs were involved in α-synuclein related pathophysiology, and AS produced the bidirectional effects on CNS under pathological and physiological conditions. Copyright © 2015 John Wiley & Sons, Ltd. Citing Literature Supporting Information Filename Description ptr5522-sup-0001-supplementary.zipapplication/x-zip-compressed, 265.4 KB Supporting info item Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume30, Issue2February 2016Pages 243-252 RelatedInformation
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