Portal de Periódicos da CAPES

iPSCs-based anti-aging therapies: Recent discoveries and future challenges

2016; Elsevier BV; Volume: 27; Linguagem: Inglês

10.1016/j.arr.2016.02.007

1872-9649

Helios Pareja‐Galeano, Fabián Sanchis‐Gomar, Laura M. Pérez, Enzo Emanuele, Alejandro Lucía, Beatriz G. Gálvez, M. Esther Gallardo,

Telomeres, Telomerase, and Senescence

The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition.