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Protective Effect of Verapamil on Shock Wave Induced Renal Tubular Dysfunction

1993; Lippincott Williams & Wilkins; Volume: 150; Issue: 1 Linguagem: Inglês

10.1016/s0022-5347(17)35388-0

1527-3792

W. L. Strohmaíer, K.-H. Bichler, J. Koch, N. Balk, D. M. Wilbert,

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No AccessJournal of Urology1 Jul 1993Protective Effect of Verapamil on Shock Wave Induced Renal Tubular Dysfunction W.L. Strohmaier, K.-H. Bichler, J. Koch, N. Balk, and D.M. Wilbert W.L. StrohmaierW.L. Strohmaier More articles by this author , K.-H. BichlerK.-H. Bichler More articles by this author , J. KochJ. Koch More articles by this author , N. BalkN. Balk More articles by this author , and D.M. WilbertD.M. Wilbert More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35388-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail In a prospective randomized study, the effects of the calcium entry blocker verapamil on shock wave induced tubular impairment were examined. A total of 24 patients with renal pelvis or caliceal stones undergoing anesthesia-free extracorporeal shock wave lithotripsy (ESWL* Dornier Medical Systems, Inc., Marietta, Georgia. ) without auxiliary measures was randomly assigned to the verapamil group (12) or the control group (12). Four doses of verapamil (80mg. each) were given orally starting the night before ESWL. Controls received no medication. To assess renal tubular function the urinary excretion of α1-microglobulin, N-acetyl-β5-glucosaminidase and Tamm-Horsfall protein were determined before, immediately, and 12 and 24hours after ESWL. After ESWL there was an increase in urinary α1-microglobulin and N-acetyl-β5-glucosaminidase, which was significantly higher in the control than in the verapamil group. Tamm-Horsfall protein, a glycoprotein synthesized by the distal tubules, decreased significantly less in the verapamil group compared to the controls. Our results indicate that verapamil exhibits a protective effect on shock wave induced tubular damage. The underlying mechanisms are not elucidated yet, and direct actions on tubular cells and interference with renal hemodynamics are to be discussed. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byPARK J, CUI Y, KIM H, OH H, KOH G and CHO K (2018) Activation of Nitric Oxide—Cyclic Guanosine Monophosphate Signaling in Kidney by Extracorporeal Shock Wave TherapyJournal of Urology, VOL. 170, NO. 6, (2459-2462), Online publication date: 1-Dec-2003.DELVECCHIO F, AUGE B, MUNVER R, BROWN S, BRIZUELA R, ZHONG P and PREMINGER G (2018) Shock Wave Lithotripsy Causes Ipsilateral Renal Injury Remote From the Focal Point: The Role of Regional VasoconstrictionJournal of Urology, VOL. 169, NO. 4, (1526-1529), Online publication date: 1-Apr-2003.MUNVER R, DELVECCHIO F, KUO R, BROWN S, ZHONG P and PREMINGER G (2018) IN VIVO ASSESSMENT OF FREE RADICAL ACTIVITY DURING SHOCK WAVE LITHOTRIPSY USING A MICRODIALYSIS SYSTEM: THE RENOPROTECTIVE ACTION OF ALLOPURINOLJournal of Urology, VOL. 167, NO. 1, (327-334), Online publication date: 1-Jan-2002.ETEROVIC D, JURETIC-KUSCIC L, CAPKUN V and DUJIC Z (2018) PYELOLITHOTOMY IMPROVES WHILE EXTRACORPOREAL LITHOTRIPSY IMPAIRS KIDNEY FUNCTIONJournal of Urology, VOL. 161, NO. 1, (39-44), Online publication date: 1-Jan-1999.Willis L, Evan A, Connors B, Reed G, Fineberg N and Lingeman J (2018) Effects of Extracorporeal Shock Wave Lithotripsy to One Kidney on Bilateral Glomerular Filtration Rate and PAH Clearance in MinipigsJournal of Urology, VOL. 156, NO. 4, (1502-1506), Online publication date: 1-Oct-1996.Strohmaier W, Carl A, Wilbert D and Bichler K (2018) Effects of Extracorporeal Shock Wave Lithotripsy on Plasma Concentrations of Endothelin and Renin in HumansJournal of Urology, VOL. 155, NO. 1, (48-51), Online publication date: 1-Jan-1996.Preminger G (2018) Editorial: Shock Wave LithotripsyJournal of Urology, VOL. 153, NO. 3, (602-603), Online publication date: 1-Mar-1995.Benyi L, Weizheng Z and Puyun L (2018) Protective Effects of Nifedipine and Allopurinol on High Energy Shock Wave Induced Acute Changes of Renal FunctionJournal of Urology, VOL. 153, NO. 3, (596-598), Online publication date: 1-Mar-1995. Volume 150Issue 1July 1993Page: 27-29 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.Keywordsurinary calculiextracorporeal shockwave lithotripsykidney tubulesverapamilMetricsAuthor Information W.L. Strohmaier More articles by this author K.-H. Bichler More articles by this author J. Koch More articles by this author N. Balk More articles by this author D.M. Wilbert More articles by this author Expand All Advertisement PDF downloadLoading ...