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Inhibitors of Inositol Monophosphatase

1999; Volume: 14; Issue: 2 Linguagem: Inglês

10.3109/14756369909036548

8755-5093

Christine M.-J. Fauroux, Sally Freeman,

Biochemical and Molecular Research

Inositol monophosphatase (IMPase) catalyses the hydrolysis of myo-inositol monophosphates to myo-inositol. which is required in the phosphatidyl inositol cell signalling pathway. Here the enzyme structure, mechanism and inhibition of IMPase are reviewed. Lithium, an effective therapy for manic depression. is an uncompetitive inhibitor. In the search for alternative inhibitors to lithium, substrate-based inhibitors, bisphosphonates, terpenoid and tropolone analogues are described.