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Donor Species Richness Determines Faecal Microbiota Transplantation Success in Inflammatory Bowel Disease

2015; Oxford University Press; Volume: 10; Issue: 4 Linguagem: Inglês

10.1093/ecco-jcc/jjv203

1876-4479

Séverine Vermeire, Marie Joossens, Kristin Verbeke, Jun Wang, Kathleen Machiels, João Sabino, Marc Ferrante, Gert Van Assche, Paul Rutgeerts, Jeroen Raes,

Helicobacter pylori-related gastroenterology studies

Background and Aims: Faecal microbiota transplantation is a successful therapy for patients with refractory Clostridium difficile infections. It has also been suggested as a treatment option for inflammatory bowel disease, given the role of the intestinal microbiota in this disease. We assessed the impact of faecal microbiota transplantation in patients with inflammatory bowel disease and studied predictors of clinical (non-)response in microbial profiles of donors and patients.