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The IASLC Lung Cancer Staging Project: Summary of Proposals for Revisions of the Classification of Lung Cancers with Multiple Pulmonary Sites of Involvement in the Forthcoming Eighth Edition of the TNM Classification

2016; Elsevier BV; Volume: 11; Issue: 5 Linguagem: Inglês

10.1016/j.jtho.2016.01.024

1556-1380

Frank C. Detterbeck, Andrew G. Nicholson, Wilbur A. Franklin, Edith M. Marom, William D. Travis, Nicolas Girard, Douglas A. Arenberg, Vanessa Bolejack, Jessica Donington, Peter J. Mazzone, L.T. Tanoue, Valerie W. Rusch, John Crowley, Hisao Asamura, Ramón Rami‐Porta, Peter Goldstraw, Ramón Rami‐Porta, Hisao Asamura, David Ball, David G. Beer, R. Guijarro, Vanessa Bolejack, Kari Chansky, John Crowley, Frank C. Detterbeck, Wilfried Eberhardt, John Edwards, Françoise Galateau-Sallé, Dorothy J. Giroux, Fergus Gleeson, Patti A. Groome, James Huang, Catherine Kennedy, Young Tae Kim, Young Tae Kim, Laura Kingsbury, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Mirella Marino, Edith M. Marom, Jan P. van Meerbeeck, Alan Mitchell, Takashi Nakano, Andrew G. Nicholson, Anna K. Nowak, Michael Peake, Thomas W. Rice, Kenneth E. Rosenzweig, Enrico Ruffini, Valerie W. Rusch, Nagahiro Saijo, Paul Van Schil, Jean‐Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F. Thomas, William D. Travis, Ming‐Sound Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi‐Long Wu, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy L. Kindler, Lee M. Krug, Kristiaan Nackaerts, Harvey I. Pass, David C. Rice, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Kazuya Kondo, Marco Lucchi, Meinoshin Okumura, Eugene H. Blackstone, Jeremy Erasmus, Douglas B. Flieder, Myrna C. B. Godoy, Jin Mo Goo, Lawrence R. Goodman, Jim Jett, Paul De Leyn, Alberto M. Marchevsky, Heber MacMahon, David P. Naidich, Morohito Okada, Marina Perlman, Charles A. Powell, Paul Van Schil, Ming‐Sound Tsao, Arne Warth, F. Abad Cavaco, Emilio Ansótegui Barrera, J. Abal Arca, Isaura Parente Lamelas, A. Arnau Obrer, R. Guijarro, David Ball, G.K. Bascom, Ana Isabel Blanco Orozco, M.A. González Castro, Matthew G. Blum, Domingo Chimondeguy, Vlado Cvijanović, Sebastián Defranchi, B. de Olaiz Navarro, I. Escobar Campuzano, Iván Macı́a, E. Fernández Araujo, F. Andreo García, Kwun M. Fong, Gloria Francisco Corral, S. Cerezo González, J. Freixinet Gilart, L. García Arangüena, S. García Barajas, Philippe Girard, Tuncay Göksel, M.T. González Budiño, Guillermo González Casaurrán, José Antonio Gullón Blanco, Jesús Hernández Hernández, H. Hernández Rodríguez, J. Herrero Collantes, M. Iglesias Heras, José Miguel Izquierdo Elena, Erik Jakobsen, S. Kostas, Pablo León Atance, Ana Núñez Ares, M. Liao, M. Losanovscky, Gustavo Lyons, R. Magaroles, L. De Esteban Júlvez, M. Mariñán Gorospe, Brian C. McCaughan, Catherine Kennedy, Rosario Melchor Íñiguez, Luis Miravet Sorribes, S. Naranjo Gozalo, C. Álvarez de Arriba, M. Núñez Delgado, J. Padilla Alarcón, Juan Carlos Peñalver Cuesta, J.S. Park, Harvey I. Pass, M.J. Pavón Fernández, M Rosenberg, Enrico Ruffini, Valerie W. Rusch, Julio Sánchez de Cos Escuín, A. Saura Vinuesa, M. Serra Mitjans, Trond‐Eirik Strand, Dragan Subotic, Stephen G. Swisher, Ricardo Mingarini Terra, C. Thomas, Kurt G. Tournoy, Paul Van Schil, Mauricio Velásquez, Yi‐Long Wu, K. Yokoi,

Radiomics and Machine Learning in Medical Imaging

Abstract Introduction Patients with lung cancer who harbor multiple pulmonary sites of disease have been challenging to classify; a subcommittee of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee was charged with developing proposals for the eighth edition of the tumor, node, and metastasis (TNM) classification to address this issue. Methods A systematic literature review and analysis of the International Association for the Study of Lung Cancer database was performed to develop proposals for revision in an iterative process involving multispecialty international input and review. Results Details of the evidence base are summarized in other articles. Four patterns of disease are recognized; the clinical presentation, pathologic correlates, and biologic behavior of these suggest specific applications of the TNM classification rules. First, it is proposed that second primary lung cancers be designated with a T, N, and M category for each tumor. Second, tumors with a separate tumor nodule of the same histologic type (either suspected or proved) should be classified according to the location of the separate nodule relative to the index tumor—T3 for a same-lobe, T4 for a same-side (different lobe), and M1a for an other-side location—with a single N and M category. Third, multiple tumors with prominent ground glass (imaging) or lepidic (histologic) features should be designated by the T category of the highest T lesion, the number or m in parentheses (#/m) to indicate the multiplicity, and a collective N and M category for all. Finally, it is proposed that diffuse pneumonic-type lung cancers be designated by size (or T3) if in one lobe, T4 if involving multiple same-side lobes, and M1a if involving both lungs with a single N and M category for all areas of involvement. Conclusion We propose to tailor TNM classification of multiple pulmonary sites of lung cancer to reflect the unique aspects of four different patterns of presentation. We hope that this will lead to more consistent classification and clarity in communication and facilitate further research in the nature and optimal treatment of these entities.