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Orthostatic myoclonus associated with Caspr2 antibodies

2016; Lippincott Williams & Wilkins; Volume: 86; Issue: 14 Linguagem: Inglês

10.1212/wnl.0000000000002547

1526-632X

Felix Gövert, Karsten Witt, Roberto Erro, Helge Hellriegel, Steffen Paschen, Eugenia Martínez‐Hernández, Klaus‐Peter Wandinger, Günther Deuschl, Josep Dalmau, Frank Leypoldt,

Genetic Neurodegenerative Diseases

Orthostatic myoclonus (OM) is a clinical phenomenon in which myoclonus of the lower limbs appears or becomes worse upon standing.1 OM usually affects patients older than 65 years and may be a frequent cause of unsteadiness upon standing in the elderly.2 Although the underlying etiology remains unclear, OM has predominantly been described in association with neurodegenerative diseases.1 We describe a patient with OM in association with antibodies against contactin-associated protein-2 (Caspr2) whose symptoms markedly improved with immunotherapy. Acknowledgment: The authors thank Dr. M. R. Rosenfeld for critical review and editing of the manuscript.