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Effects of Ultrasonic Exposure Parameters on Myocardial Lesions Induced by High-Intensity Focused Ultrasound

2006; Wiley; Volume: 25; Issue: 11 Linguagem: Inglês

10.7863/jum.2006.25.11.1375

1550-9613

Kana Fujikura, Ryo Otsuka, Andrew Kalisz, Jeffrey A. Ketterling, Zhezhen Jin, Robert R. Sciacca, Charles C. Marboe, Jie Wang, Robert Muratore, Ernest J. Feleppa, Shunichi Homma,

Ultrasonics and Acoustic Wave Propagation

Journal of Ultrasound in MedicineVolume 25, Issue 11 p. 1375-1386 Article Effects of Ultrasonic Exposure Parameters on Myocardial Lesions Induced by High-Intensity Focused Ultrasound Kana Fujikura MD, Corresponding Author Kana Fujikura MD kf2113@columbia.edu Columbia Presbyterian Medical Center, New York, New York USAAddress correspondence to Kana Fujikura, MD, Department of Biomedical Engineering, Columbia University, Columbia Presbyterian Medical Center, 622 W 168th St, VC12-234, New York, NY 10032 USA.Search for more papers by this authorRyo Otsuka MD, Ryo Otsuka MD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorAndrew Kalisz MSEE, Andrew Kalisz MSEE Riverside Research Institute, New York, New York USASearch for more papers by this authorJeffrey A. Ketterling PhD, Jeffrey A. Ketterling PhD Riverside Research Institute, New York, New York USASearch for more papers by this authorZhezhen Jin PhD, Zhezhen Jin PhD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorRobert R. Sciacca EngScD, Robert R. Sciacca EngScD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorCharles C. Marboe MD, Charles C. Marboe MD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorJie Wang MD, PhD, Jie Wang MD, PhD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorRobert Muratore PhD, Robert Muratore PhD Riverside Research Institute, New York, New York USASearch for more papers by this authorErnest J. Feleppa PhD, Ernest J. Feleppa PhD Riverside Research Institute, New York, New York USASearch for more papers by this authorShunichi Homma MD, Shunichi Homma MD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this author Kana Fujikura MD, Corresponding Author Kana Fujikura MD kf2113@columbia.edu Columbia Presbyterian Medical Center, New York, New York USAAddress correspondence to Kana Fujikura, MD, Department of Biomedical Engineering, Columbia University, Columbia Presbyterian Medical Center, 622 W 168th St, VC12-234, New York, NY 10032 USA.Search for more papers by this authorRyo Otsuka MD, Ryo Otsuka MD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorAndrew Kalisz MSEE, Andrew Kalisz MSEE Riverside Research Institute, New York, New York USASearch for more papers by this authorJeffrey A. Ketterling PhD, Jeffrey A. Ketterling PhD Riverside Research Institute, New York, New York USASearch for more papers by this authorZhezhen Jin PhD, Zhezhen Jin PhD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorRobert R. Sciacca EngScD, Robert R. Sciacca EngScD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorCharles C. Marboe MD, Charles C. Marboe MD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorJie Wang MD, PhD, Jie Wang MD, PhD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this authorRobert Muratore PhD, Robert Muratore PhD Riverside Research Institute, New York, New York USASearch for more papers by this authorErnest J. Feleppa PhD, Ernest J. Feleppa PhD Riverside Research Institute, New York, New York USASearch for more papers by this authorShunichi Homma MD, Shunichi Homma MD Columbia Presbyterian Medical Center, New York, New York USASearch for more papers by this author First published: 01 November 2006 https://doi.org/10.7863/jum.2006.25.11.1375Citations: 12Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective. This study evaluated variables relevant to creating myocardial lesions using high-intensity focused ultrasound (HIFU). Without an effective means of tracking heart motion, lesion formation in the moving ventricle can be accomplished by intermittent delivery of HIFU energy synchronized by electrocardiographic triggering. In anticipation of future clinical applications, multiple lesions were created by brief HIFU pulses in calf myocardial tissue ex vivo. Methods. Experiments used f-number 1.1 spherical cap HIFU transducers operating near 5 MHz with in situ spatial average intensities of 13 and 7.4 kW/cm2 at corresponding depths of 10 and 25 mm in the tissue. The distance from the HIFU transducer to the tissue surface was measured with a 7.5-MHz A-mode transducer coaxial and confocal with the HIFU transducer. After exposures, fresh, unstained tissue was dissected to measure visible lesion length and width. Lesion dimensions were plotted as functions of pulse parameters, cardiac structure, tissue temperature, and focal depth. Results. Lesion size in ex vivo tissue depended strongly on the total exposure time but did not depend strongly on pulse duration. Lesion width depended strongly on the pulse-to-pulse interval, and lesion width and length depended strongly on the initial tissue temperature. Conclusions. High-intensity focused ultrasound creates well-demarcated lesions in ex vivo cardiac muscle without damaging intervening or distal tissue. These initial studies suggest that HIFU offers an effective, noninvasive method for ablating myocardial tissues to treat several important cardiac diseases. Citing Literature Volume25, Issue11November 2006Pages 1375-1386 RelatedInformation