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Inflammatory markers and suicidal attempts in depressed patients: A review

2016; SAGE Publishing; Volume: 29; Issue: 4 Linguagem: Inglês

10.1177/0394632015623793

2058-7384

Stefano Marini, Federica Vellante, Ilaria Matarazzo, Domenico De Berardis, Nicola Serroni, D. Gianfelice, Luigi Olivieri, Fulvia Di Renzo, Anna Di Marco, Michele Fornaro, Laura Orsolini, Alessandro Valchera, Felice Iasevoli, Monica Mazza, Giampaolo Perna, Giovanni Martinotti, Massimo Di Giannantonio,

Maternal Mental Health During Pregnancy and Postpartum

Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.