Exercise training has protective effects in monocrotaline induced pulmonary hypertension
2010; Wiley; Volume: 24; Issue: S1 Linguagem: Inglês
10.1096/fasebj.24.1_supplement.1023.9
ISSN1530-6860
AutoresDaniel Moreira‐Gonçalves, Tiago Henriques‐Coelho, Hélder Fonseca, Nádia Gonçalves, Manuel J. Ferreira‐Pinto, Marina Dias‐Neto, Francisco Vasques‐Nóvoa, Adelino Leite‐Moreira, José Alberto Duarte,
Tópico(s)Pulmonary Hypertension Research and Treatments
ResumoThe use of exercise training as a therapeutic and/or preventive strategy is gaining interest in pulmonary arterial hypertension (PH). We aimed to study the influence of endurance exercise training in monocrotaline (MCT) induced PH. Male Wistar rats were randomly divided according the following groups: i) sedentary with MCT (60 mg/kg sc) or vehicle (SED+MCT and SED+V), ii) 4 week‐exercise training before MCT or vehicle injection (EX+MCT and EX+V) and iii) 4 week‐exercise training after MCT or vehicle injection (MCT+EX and V+MCT). Hemodynamic bi‐ventricular instrumentation with conductance catheters was assessed at 4 weeks after MCT or vehicle injection. After cardiac instrumentation, a morphometric evaluation was performed. In SED+MCT group, MCT induced body and muscular cachexia, RV hypertrophy, RV peak systolic pressure increase, and RV relaxation disturbances. Both groups submitted to exercise training did not develop body or muscular cachexia, presented less RV hypertrophy and no relaxation disturbances. There were no significant differences among groups injected with vehicle. Exercise significantly reduced mortality rate after 4 weeks of MCT injection. We concluded that exercise training seems to have protective effects in MCT model of PH. Supported by FCT: SFRH/BD/33123/2007
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