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Evidence of Porphyrin‐Like Structures in Natural Melanin Pigments Using Electrochemical Fingerprinting

2016; Volume: 28; Issue: 16 Linguagem: Inglês

10.1002/adma.201504650

1521-4095

Young Jo Kim, Abhishek Khetan, Wei Wu, Sang‐Eun Chun, Venkatasubramanian Viswanathan, Jay Whitacre, Christopher J. Bettinger,

Antioxidant Activity and Oxidative Stress

Advanced MaterialsVolume 28, Issue 16 p. 3173-3180 Communication Evidence of Porphyrin-Like Structures in Natural Melanin Pigments Using Electrochemical Fingerprinting Young Jo Kim, Young Jo Kim Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USASearch for more papers by this authorAbhishek Khetan, Abhishek Khetan Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USA Institute for Combustion Technology, RWTH, Aachen, 52062 GermanySearch for more papers by this authorWei Wu, Wei Wu Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USASearch for more papers by this authorSang-Eun Chun, Sang-Eun Chun Department of Chemistry, University of Oregon, Eugene, OR, 97403 USASearch for more papers by this authorVenkatasubramanian Viswanathan, Corresponding Author Venkatasubramanian Viswanathan Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USAE-mail: venkvis@cmu.edu, whitacre@andrew.cmu.edu, cbetting@andrew.cmu.eduSearch for more papers by this authorJay F. Whitacre, Corresponding Author Jay F. Whitacre Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USAE-mail: venkvis@cmu.edu, whitacre@andrew.cmu.edu, cbetting@andrew.cmu.eduSearch for more papers by this authorChristopher J. Bettinger, Corresponding Author Christopher J. Bettinger Department of Materials Science and Engineering, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USA McGowan Institute of Regenerative Medicine, 450 Technology Drive, Suite 300, Pittsburgh, PA, 15219 USAE-mail: venkvis@cmu.edu, whitacre@andrew.cmu.edu, cbetting@andrew.cmu.eduSearch for more papers by this author Young Jo Kim, Young Jo Kim Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USASearch for more papers by this authorAbhishek Khetan, Abhishek Khetan Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USA Institute for Combustion Technology, RWTH, Aachen, 52062 GermanySearch for more papers by this authorWei Wu, Wei Wu Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USASearch for more papers by this authorSang-Eun Chun, Sang-Eun Chun Department of Chemistry, University of Oregon, Eugene, OR, 97403 USASearch for more papers by this authorVenkatasubramanian Viswanathan, Corresponding Author Venkatasubramanian Viswanathan Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USAE-mail: venkvis@cmu.edu, whitacre@andrew.cmu.edu, cbetting@andrew.cmu.eduSearch for more papers by this authorJay F. Whitacre, Corresponding Author Jay F. Whitacre Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USAE-mail: venkvis@cmu.edu, whitacre@andrew.cmu.edu, cbetting@andrew.cmu.eduSearch for more papers by this authorChristopher J. Bettinger, Corresponding Author Christopher J. Bettinger Department of Materials Science and Engineering, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USA McGowan Institute of Regenerative Medicine, 450 Technology Drive, Suite 300, Pittsburgh, PA, 15219 USAE-mail: venkvis@cmu.edu, whitacre@andrew.cmu.edu, cbetting@andrew.cmu.eduSearch for more papers by this author First published: 29 February 2016 https://doi.org/10.1002/adma.201504650Citations: 67Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Eumelanins are extended heterogeneous biopolymers composed of molecular subunits with ambiguous macromolecular topology. Here, an electrochemical fingerprinting technique is described, which suggests that natural eumelanin pigments contain indole-based tetramers that are arranged into porphyrin-like domains. Spectroscopy and density functional theory calculations suggest that sodium ions undergo occupancy-dependent stepwise insertion into the core of porphyrin-like tetramers in natural eumelanins at discrete potentials. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description adma201504650-sup-0001-S1.pdf3.7 MB Supplementary Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume28, Issue16April 27, 2016Pages 3173-3180 RelatedInformation