Portal de Periódicos da CAPES

Characterisation and In Vitro Cytotoxicity ofTriorganophosphinegold(I) 2‐Mercaptobenzoate Complexes

1999; Hindawi Publishing Corporation; Volume: 6; Issue: 1 Linguagem: Inglês

10.1155/mbd.1999.31

0793-0291

Dick de Vos, Phil Clements, Simon M. Pyke, Douglas R. Smyth, Edward R. T. Tiekink,

Polyoxometalates: Synthesis and Applications

The preparation and full NMR ( 1 H, 13 C and 31 P) characterisation of three R 3 PAu (2mba) complexes, Where R = Et, Ph and Cy, and 2mba is the anion derived from 2‐mercaptobenzoic acid is reported. An interesting solvent dependence in the 1 H spectra is rationalised in terms of competing intra‐ and inter‐molecular hydrogen bonding. An X‐ray analysis of the [Ph 3 PAu(2mba)] species reveals a linear P—Au—S arrangement and association in the lattice via the familar carboxylic acid dimer motif. The in Vitro cytotoxicity against seven human tumout lines is also described. The complexes display moderate to very high activity. Particularly noteworthy is their greater activity against the H226 cell line (non‐small cell lung cancer) compared with that displayed by a range of cytotoxic drugs.