Artigo Acesso aberto Revisado por pares

PET Imaging of Tau Deposition in the Aging Human Brain

2016; Cell Press; Volume: 89; Issue: 5 Linguagem: Inglês

10.1016/j.neuron.2016.01.028

ISSN

1097-4199

Autores

Michael Schöll, Samuel N. Lockhart, Daniel R. Schonhaut, James P. O’Neil, Mustafa Janabi, Rik Ossenkoppele, Suzanne L. Baker, Jacob W. Vogel, Jamie Faria, Henry Schwimmer, Gil D. Rabinovici, William J. Jagust,

Tópico(s)

Alzheimer's disease research and treatments

Resumo

Summary Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18 F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition. Video Abstract

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