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The role of N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications

2015; Impact Journals LLC; Volume: 7; Issue: 15 Linguagem: Inglês

10.18632/oncotarget.6283

1949-2553

Julio Cesar Madureira de‐Freitas‐Junior, José Andrés Morgado‐Díaz,

Carbohydrate Chemistry and Synthesis

// Julio Cesar Madureira de Freitas Junior 1 and José Andrés Morgado-Díaz 1 1 Cellular Biology Program, Structural Biology Group, Brazilian National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil Correspondence to: Julio Cesar Madureira de Freitas Junior, email: // José Andrés Morgado-Díaz, email: // Keywords : N-glycans, colorectal cancer, biomarkers, glycosylation, carcinoma Received : May 28, 2015 Accepted : October 22, 2015 Published : November 02, 2015 Abstract Changes in glycosylation, which is one of the most common protein post-translational modifications, are considered to be a hallmark of cancer. N -glycans can modulate cell migration, cell-cell adhesion, cell signaling, growth and metastasis. The colorectal cancer (CRC) is a leading cause of cancer-related mortality and the correlation between CRC progression and changes in the pattern of expression of N -glycans is being considered in the search for new biomarkers. Here, we review the role of N -glycans in CRC cell biology. The perspectives on emerging N -glycan-related anticancer therapies, along with new insights and challenges, are also discussed.