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BIBTEX RIS

Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults

1997; American Society for Microbiology; Volume: 65; Issue: 11 Linguagem: Inglês

10.1128/iai.65.11.4873-4876.1997

ISSN

1098-5522

Autores

Cheikh Momar Nguer, Tamsir O. Diallo, Ababacar Diouf, Adama Tall, Alioune Dièye, Ronald Perraut, Olivier Garraud,

Tópico(s)

Vector-borne infectious diseases

Resumo

This study shows markedly different isotype distributions of antibodies to asexual blood stages of Plasmodium falciparum and to merozoite surface protein 1 in clinically immune Senegalese adults depending on the study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where transmission is perennial compared to settings where it is seasonal. This suggests a role for antibody class and/or subclass production and utilization in the regulation of protective immunity to such antigens.

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