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Lack of antiemetic effect of high-dose metoclopramide.

1985; Lippincott Williams & Wilkins; Volume: 3; Issue: 9 Linguagem: Inglês

10.1200/jco.1985.3.9.1273

1527-7755

Reinhard von Roemeling, Neal P. Christiansen, William J.M. Hrushesky,

Chemotherapy-induced organ toxicity mitigation

Sixteen of 26 patients given 51 courses of treatment of the doxorubicin and cisplatin combination with no antiemetic therapy suffered the same number of vomiting episodes and had the same duration of vomiting as did the remaining ten patients given 20 cycles of this chemotherapy plus the standard high-dose metoclopramide regimen. This antiemetic regimen caused significant side effects in one fifth of the patients receiving it.