Rat Parotid Gland Pathophysiology Following 137 Cs Irradiation
1982; Radiation Research Society; Volume: 90; Issue: 2 Linguagem: Inglês
10.2307/3575710
ISSN1938-5404
AutoresJames Rice, Kenneth T. Izutsu, Edmond L. Truelove, Thomas W. Menard, Marc W. Anderson, Thomas Hellman Morton, Ivens A. Siegel,
Tópico(s)Olfactory and Sensory Function Studies
ResumoChanges in rat parotid gland function were measured between 3 and 30 days following exposure to 1800 R of137 Cs irradiation to the head. Glandular fluid secretion capability as indicated by volume of secretion, maximum rate of secretion, and duration of secretion following pilocarpine stimulation decreased concomitantly with gland weight following irradiation. Thus gland weight is probably indicative of residual glandular potential for fluid secretion following irradiation. The relation between salivary sodium concentration and flow rate was assumed to be indicative of glandular electrolyte transport capability. Salivary sodium concentrations were not elevated over control values at any flow rate. Therefore, there is no evidence for an irradiation-induced defect in the ductal sodium resorption mechanism. Rather, the observed salivary sodium changes are consistent with a decrease in the relative glandular proportion of acini to ducts.
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