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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Short Communication: Molecular Characteristics of HIV Type 1 Circulating in São Paulo, Brazil

2005; Mary Ann Liebert, Inc.; Volume: 21; Issue: 7 Linguagem: Inglês

10.1089/aid.2005.21.673

ISSN

1931-8405

Autores

Luís Fernando de Macedo Brígido, Heitor Moreira Franco, Renata Marconi Custódio, Carmen A. Freitas Oliveira, João Leandro Ferreira, Margareth da Eira, Fernando Bergel, Fabio Araújo, Jose R. Carvalheiro, Rosângela Rodrigues,

Tópico(s)

HIV/AIDS Research and Interventions

Resumo

Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gene were common both in contemporary and pre-HAART era isolates, some significantly associated with the viral clade. HIV-1 clade B was preponderant, in 79%, with 11% clade F and one case of HIV-1 C. Recently infected women had a significantly higher proportion of non-B clade HIV-1. A mosaic pol was observed in 9%, all B/F except for one G mosaic. A CRF-12–BF structure, observed in 20% of B/F pol mosaics, provides evidence for an epidemic relationship in the major South American metropolitan areas.

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